Trends in coordination of rhenium organometallic complexes in the Protein Data Bank

A Brink, FJF Jacobs, JR Helliwell
IUCrJ 9 (2022) 180-193.
Science Published: (Mar/2025)
DOI: https://doi.org/10.1107/S2052252522000665
Abstract:

Radiopharmaceutical development has similar overall characteristics to any biomedical drug development requiring a compound's stability, aqueous solubility and selectivity to a specific disease site. However, organometallic complexes containing 188/186Re or 99mTc involve a d-block transition-metal radioactive isotope and therefore bring additional factors such as metal oxidation states, isotope purity and half life into play. This topical review is focused on the development of …